Qianxia Zhang, PhD, Postdoctoral Fellow Boston Children's Hospital The mammalian adaptive immune system relies on a series of intricate selection process on immune repertoires to enforce a robust discrimination between self and non-self, which is the key to prevent autoimmunity. However, since self-antigens are shared in tumor tissues, robust self-tolerance can also limit effective anti-tumor immune responses. Therefore, a clear molecular understanding of how the immune system discriminate self and non-self can provide therapeutic guidance for autoimmune disease and cancer immunotherapies.
